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Milk Thistle SupplementPosted on February 24, 2010. Is it safe to use milk thistle supplement on a daily basis to help protect the liver? I take 400 mg per day to help my liver as I have been a heavy drinker, cut now though. I'm 28, female, normal weight. Yes, it is perfectly safe to take milk thistle long term Consult your doctor, sylimarin has not been shown that the major liver in controlled studies. CommentsThere are no comments.Leave a Comment | Popular Posts My Friends |